Indirect Tertiary Alcohol Enantiocontrol by Acylative Organocatalytic Kinetic Resolution
نویسندگان
چکیده
The stereocontrol of tertiary alcohols represents a recurrent challenge in organic synthesis. In the present paper, we describe simple, efficient, and indirect method to enantioselectively prepare through chiral isothiourea catalyzed selective acylation adjacent secondary alcohols. This transformation enables kinetic resolution (KR) easily prepared racemic diastereoenriched secondary/tertiary diols providing both monoesters starting highly enantioenriched forms (s-value >200).
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c01261